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| PATRICIO I. MENESES Associate Professor |
Department of Biological Sciences
Fordham University
441 East Fordham Road
Bronx, NY 10458 |
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Phone: 718-817-3656 (office), 718-817-3658 (lab)
Fax: 718-817-3645
pmeneses@fordham.edu
http://www.meneseslab.com
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Education and Training
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BS, SUNY Stony Brook, 1990
PhD, Weill-Cornell Medical College, 1999
Postdoc, Harvard Medical School
Senior Research Investigator, University of Pennsylvania School of Medicine, Dept. of Neurology, Microbiology, & Immunology
Assistant Professor, Rosalind Franklin University of Medicine and Science, Dept. of Microbiology and Immunology, 2006-2011
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Research Interests |
| Infection associated cancers are increasing at an alarming rate. Human papillomavirus (HPV) infection is estimated to cause one-third of the 1.5 million cancers attributed to viruses. The HPV related cancers include cervical cancer, head and neck squamous carcinoma, and anal cancer. Our long-term goal is to understand the basic processes that are necessary to establish HPV infection. Understanding the process of initial viral entry and trafficking can result in novel approaches to decrease infection and lessen the burden of HPV related cancers. |
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| Selected Publications |
Dabydeen SA, Meneses PI. Smurf2 alters BPV1 trafficking and decreases infection. Arch Virol. 2011 May;156(5):827-38. Epub 2011 Feb 12.
Abban CY, Meneses PI. Usage of heparan sulfate, integrins, and FAK in HPV16 infection. Virology. 2010 Jul 20;403(1):1-16.
Dabydeen SA, Meneses PI. The role of NH4CI and cysteine proteases in Human Papillomavirus type 16 infection Virology Journal 2009, 6:109.
Young A, Gentzch M, Abban CY, Jia Y, Meneses PI, Bridges RJ, Breadbury NA. Dynasore inhibits removal of wild-type and rF508 CFTR from the plasma membrane. Biochem J. 2009 Jul 15;421(3):377-85.
Laniosz, V., Dabydeen, S.A., Havens, M. A. & Meneses, P. I. (2009) Human Papillomavirus Type 16 Infection of Human Keratinocytes Requires Clathrin, Caveolin-1, and is Brefeldin A-Sensitive. J. Virol., JVI.00576-09. Epub 2009, June 3rd.
Holthusen KA, Gonzalez AM, Meneses PI. "Guanine exchange factor Vav2: a novel potential target for the development of drugs effectivein the prevention of papillomavirus infection and disease. Am J Ther. 2009 Nov-Dec;16(6):496-507.
Laniosz V, Holthusen KA, Meneses PI. “Bovine papillomavirus type 1: from clathrin to caveolin.” J Virol., 2008 Jul;82 (13):6288-98. Epub, 2008, Apr 16.
Cynthia Y Abban, Neil A Bradbury, Patricio I. Meneses. HPV16 and BPV1 infection can be blocked by the dynamin inhibitor dynasore. American Journal of Therapeutics. 2008. Jul-Aug; 15 (4):304-311.
Masanao MurakamiY, Patricio I. MenesesY, Jason Knight, Ke Lan, Rajeev Kaul, Subhash C. Verma and Erle S. Robertson. Nm23-H1 modulates the activity of the guanine exchange factor Dbl-1. International Journal of Cancer, 2008. Aug. 1; 123 (3): 500-510. Y - equal contributors
Masanao Murakami, Patricio I. Meneses, Ke Lan and Erle S. Robertson. “The Suppressor of Metastasis Nm23-H1 Interacts with the Cdc42 Rho Family Member and the Pleckstrin Homology Domain of Oncoprotein Dbl-1 to Suppress Cell Migration”. Cancer Biology and Therapy. 2008. Vol 7; (5): 677-688.
Laniosz V, Nguyen KC, Meneses PI. Bovine papillomavirus type 1 infection is mediated by SNARE syntaxin 18”. J Virol. 2007 Jul;81(14):7435-48. Epub 2007, May 2.
Le, T.T., J.H. Levan and P.I. Meneses. "High-performance and grid computing for study and research in infectious diseases", Scientific conference on infectious disease and tropical medicine, pp 111-127, 2006.
Meneses, P.I., and E.S. Robertson. "Papillomavirus biology and therapeutic approaches," Gene. Ther. Biol., 9:217-228, 2005.
Bossis, I., R.B.S. Roden, R. Gambhira, R. Yang, M. Tagaya, P.M. Howley and P.I. Meneses. "Interaction of tSNARE Syntaxin 18 with the papillomavirus minor capsid protein mediates infection," J. Virol., 79:6723-6731, 2005.
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