Selected Peer-Reviewed Publications
Gomez B, Zhu J, Recio-Pinto E, Thornhill WB (2017). Amino acid properties of trafficking determinants in the outer pore-forming region of Kv1 potassium channels in cell lines. Cell Biochemistry and Biophysics 75:25-33.
Watanabe I, Zhu J, Recio-Pinto E, Thornhill WB (2015). The degree of N-glycosylation affects the trafficking and cell expression levels of Kv1.4 potassium channels. J. Membrane Biology 248:187-196.
Zhu J, Yan J, Thornhill WB (2014). The Kv1.3 potassium channel is localized to the cis-Golgi and Kv1.6 is localized to the endoplasmic reticulum in rat astrocytes. FEBS J. 281:3433-3445.
Zhao J, Zhu J, & Thornhill WB (2013). Spinocerebellar ataxia-13 Kv3.3 potassium channels: Arginine-to-Histidine mutations affect both functional and protein expression on the cell surface. Biochem. J. (England): 454:259-265.
Zhu J, Yan J, & Thornhill WB (2012). N-Glycosylation promotes the cell surface expression of Kv1.3 potassium channels. FEBS J. 279:2632-2544
Zhu J, Alsaber R, Zhao J, Ribeiro-Hurley E, & Thornhill WB (2012). Characterization of the Kv1.1 I262T and S342I mutations associated with episodic ataxia 1 with distinct phenotypes. Arch. Biochem. Biophys. 524:99-105.
Von Bergen Granell AE, Palter KB, Akan I, Aich U, Yarema KJ, Betenbaugh MJ, Thornhill WB, Recio-Pinto E (2011). DmSAS is required for sialic acid biosynthesis in cultured Drosophila third instar larvae CNS neurons. ACS Chemical Biology 6:1287 1295.
Zhu J, Recio-Pinto E, Hartwig T, Sellers W, Yan J, & Thornhill WB (2009). The Kv1.2 potassium channel: the position of an N-glycan on the extracellular linkers affects its protein expression and function. Brain Res. 1251:16-29.
Zhu J, Gomez B, Watanabe I, & Thornhill WB (2007). Kv1 potassium channel C-terminus constant HRETE region: arginine substitution affects surface protein level and conductance level of subfamily members differentially. Mol. Memb. Biol. (England), 24:1-12.
Watanabe I, Zhu J, Sutachan JJ, Gottschalk A, Recio-Pinto E, & Thornhill WB (2007). The glycosylation state of Kv1.2 potassium channels affects trafficking, gating, and simulated action potentials. Brain Res. 1144:1-18.
Sutachan JJ, Watanabe I, Zhu J, Gottschalk A, Recio-Pinto E, & Thornhill WB (2005). Effects of Kv1.1 channel glycosylation on C- type inactivation and stimulated action potentials. Brain Res. 1058:30-43.
Zhu J, Gomez B, Watanabe I, & Thornhill WB (2005). Amino acids in the pore region of Kv1 potassium channels dictate cell surface protein levels: a possible trafficking code in the Kv1 subfamily. Biochem. J. (England) 388:355-362.
Watanabe I, Zhu J, Recio-Pinto E, & Thornhill WB (2004). Glycosylation affects the protein stability and cell surface expression of Kv1.4 but not Kv1.1 potassium channels: a pore region determinant dictates the effect of glycosylation on trafficking. J. Biol. Chem. J. Biol. Chem. 279:8879-8885.
Zhu J, Watanabe I, Gomez B, & Thornhill WB (2003). Heteromeric Kv1 potassium channel expression: amino acid determinants involved in processing and trafficking to the cell surface. J. Biol. Chem. 278:25558-25567.
Zhu J, Watanabe I, Gomez B, & Thornhill WB (2003). Trafficking of Kv1.4 potassium channels: interdependence of a pore region determinant and a cytoplasmic C-terminal VXXSL determinant in regulating cell surface trafficking. Biochem. J. (England) 375:761-768.
Zhu J, Watanabe I, Poholek A, Koss M, Gomez B, Yan C, Recio-Pinto E & Thornhill WB (2003). Allowed N-glycosylation sites on the Kv1.2 potassium channel S1-S2 linker: implications for linker secondary structure and the glycosylation effect on function. Biochem. J. (England) 375:769-775.
Watanabe I, Wang HG, Sutachan JJ, Zhu J, Recio-Pinto E, & Thornhill WB (2003). Glycosylation affects Kv1.1 potassium channel gating a combined surface potential and a cooperative subunit interaction mechanism. J. Physiol. (England) 550:51-66.
Thornhill WB, Watanabe I, Sutachan JJ, Wu MB, Wu X, Zhu J, & Recio-Pinto E (2003). Molecular cloning and functional expression of a Kv1.1-like potassium channel from the electric organ of Electrophorus electricus. J. Memb. Biol. 196:1-8.
Castillo C, Thornhill WB, Zhu J, & Recio-Pinto E (2003). The permeation and activation properties of brain sodium channels changes during development. Develop. Brain Res. 144:99-106.
Zhu J, Watanabe I, Gomez B, & Thornhill WB (2001). Determinants involved in Kv1 potassium channel folding in the endoplasmic reticulum, glycosylation in the Golgi, and cell surface expression. J. Biol. Chem. 276:39419-39427.
Zhu L, Wu X, Wu MB, Chan KW, Logothetis DE, & Thornhill WB (2001). Cloning and characterization of G protein-gated inward rectifier K+ channel (GIRK1) isoforms from heart and brain. J. Mol. Neurosci 16:21-32.
Pabon A, Chan KW, Sui JL, Wu X, Logothetis DE, & Thornhill WB (2000). Glycosylation of GIRK1 at N119 and ROMK1 at N117 have different consequences in potassium channel function. J. Biol. Chem. 275:30677-30682.
Castaneda-Castellanos D, Cano M, Wang JKT, Corbett A, Benson D, Blanck TJJ, Thornhill WB, & Recio-Pinto E (2000). CNS voltage-dependent Na+ channel expression and distribution in an undifferentiated and differentiated CNS cell line. Brain Res. 866:281-285.
Jing J, Chikvashvili D, Singer-Laht D, Thornhill WB, Reuveny E, & Lotan I (1999). Fast inactivation of a brain K+ channel composed of Kv1.1 and Kv1.1 subunits modulated by G protein subunits. EMBO J 18:1245-1256.
Levi M, Jie J, Chikvashvili D, Thornhill WB, & Lotan I (1998). Activation of metabotropic glutamate receptor and protein kinase C reduce the extent of inactivation of the K+ channel Kv1.1/Kvbeta1.1 via dephosphorylation of Kv1.1. J. Biol. Chem. 273: 6495- 6502.
Jing J, Peretz T, Singer-Lahat D, Chikavshvili D, Thornhill WB, & Lotan I (1997). Inactivation of a voltage-dependent K+ channel by beta-subunit: modulation by a phosphorylation-dependent interaction between the distal C-terminus of alpha-subunit and cytoskeleton. J. Biol. Chem. 272:14021-14024.
Ponce A, Vega-Saenz de Miera E, Kentros C, Moreno H, Thornhill WB, & Rudy B (1997). K+ channel subunit isoforms with divergent carboxy-terminal sequences carry distinct membrane targeting signals. J. Memb. Biol. 159:149-159.
Castillo C, Diaz ME, Balbi D, Thornhill WB, & Recio-Pinto E (1997). Changes in sodium channel function during postnatal brain development reflect increases in the level of channel sialidation. Develop. Brain Res. 104:119-130.
Peretz T, Levin G, Moran O, Thornhill WB, Chikavshvili D, & Lotan I (1996). Modulation by protein kinase C of rat brain delayed-rectifier K+ channel expressed in Xenopus oocytes. FEBS LET 381:71-76.
Ponce A, Bueno E, Kentros C, Vega-Saenz de Miera E, Chow L, Hillman D, Chen S, Wu MB, Wu X, Zhu L, Rudy B, & Thornhill WB (1996). G protein-gated inward rectifier K channel proteins (GIRK1) are present in the soma and dendrites as well as nerve terminals of specific neurons in the brain. J. Neurosci. 16: 1990-2001.
Thornhill WB, Wu MB, Jiang X, Wu X, Morgan P, & Margiotta JF (1996). Expression of Kv1.1 delayed-rectifier potassium channels in Lec mutant CHO cell lines reveals a role for sialidation in channel function. J. Biol. Chem. 271:19093-19098.
Levin G, Chikvashvili D, Singer-Lahat D, Peretz T, Thornhill WB, & Lotan I (1996). Phosphorylation of a K+ channel alpha- subunit modulates the inactivation conferred by a beta-subunit; involvement of cytoskeleton. J. Biol. Chem. 271:29321-29328.
Weiser M, Bueno E, Sekirnjak C, Martone ME, Baker H, Hillman D, Thornhill WB, Ellisman M, & Rudy B (1995). The potassium channel subunit Kv3.1b is localized to somatic and axonal membranes of specific populations of CNS neurons. J. Neurosci. 15:4298-4314.
Levin G, Keren T, Peretz T, Chikavshvili D, Thornhill WB, & Lotan I (1995). Regulation of RCK1 currents with a cAMP analog via enchanced protein synthesis and direct channel phosphorylation. J. Biol. Chem. 270:14611-14618.
Moreno H, Kentros C, Bueno E, Weiser M, Herdandez A, Vega-Saenz de Miera E, Thornhill WB, & Rudy B (1995). Thalamocortical projections have a K+ channel that is phosphorylated and modulated by cAMP-dependent protein kinase. J. Neurosci. 15:5486-5501.