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Martin Di Grandi

PhD

Assistant Professor of Chemistry
Offices: Lincoln Center 808C | Rose Hill JMH 538
Email: mdigrandi@fordham.edu
Phone: Lincoln Center: 212-636-7141 | Rose Hill: 718-817-4447

Education

PhD, March 1990, New York University
BSc, May 1984, Fordham University

Research Interests

Using medicinal chemistry to improve the biological activity of natural products for the treatment of viral infections and cancer; the total synthesis of natural products.

Selected Publications

Hu, Y.; Xiang, J. S; Di Grandi, M. J.; Du, X.; Ipek, M.; Laakso, L. M.; Li, J.; Li, W.; Rush, T. S.; Schmid, J.; Skotnicki, J. S.; Tam, S.; Thomason, J. R.; Wang, Q.; Levin, J. I. “Potent, Selective And Orally Bioavailable Matrix Metalloproteinase-13 Inhibitors For The Treatment Of Osteoarthritis”,BioOrg. Med. Chem., 2005, 13, 6629-6644.

Nittoli, T.; Curran, K.; Insaf, S.; Di Grandi, M.; Orlowski, M.; Chopra, R.V; Agarwal, A.; Howe, A. Y. M.; Prashad, A.; Floyd, M. B.; Johnson, B.; Sutherland, A.; Wheless, K.; Feld, B.; O'Connell, J.; Mansour, T. S.; Bloom, J. “Identification Of Anthranilic Acid Derivatives As A Novel Class Of Allosteric Inhibitors Of Hepatitis C NS5B Polymerase”, J. Med. Chem.,2007, 50(9), 2108-2116; Corrigendum: J. Med. Chem., 2007, 50(24), 6290.

Di Grandi, M.; Berger, D. M.; Hopper, D. W.; Zhang, C.; Dutia, M.; Dunnick, A. L.; Torres, N.; Levin, J. I.; Diamantidis; G.; Zapf, C. W.; Bloom, J. D.; Hu, Y.; Powell, D.; Wojciechowicz; D.; Collins, K.; Frommer, E. “Novel Pyrazolopyrimidines As Highly Potent B-RAF Inhibitors”, Bioorg. Med. Chem. Lett., 2009, 19(24), 6957-6961.

Di Grandi, M.; Olson, M.; Prashad, A. S.; Bebernitz, G.; Luckay, A.; Mullen, S.; Hu, Y.; Krishnamurthy, G.; Pitts, K.; O’Connell, J. “Small Molecule Inhibitors Of HIV RT Ribonuclease H”, BioOrg. Med. Chem. Lett., 2010, 20(1), 398-402.

Selected Patents

Olson, M. W.; Di Grandi, M.; Prashad, A. “Preparation Of Hydantoins Having RNASE Modulatory Activity.” U.S. Pat. Appl. Publ.2005; 16 PP.; US 2005203156 A1.

Olson, M. W.; Di Grandi, M.; Prashad, A. “Carbamates as HIV Anti-Viral Agents.” U.S. Pat. Appl. Publ. 2005, 15 PP.; US 2005203176 A1.

Hu, Y.; Sum, F.-W.; Di Grandi, M.; Norton, E. “Preparation Of Anilino-Pyrimidine Phenyl And Benzothiophene Analogs As Protein Kinase Inhibitors For Treating Inflammatory, Autoimmune, Cardiovascular And Other Disease.” U.S. Pat. Appl. Publ. 2007, 36 PP; US 2007244140 A1.

Olson, M.; Di Grandi, M.; Prashad, A. “Preparation Of 1,2-Dihydroquinoline Derivatives As Inhibitors Of RNASE H And HIV Reverse Transcriptase.” 2009, US Patent 7,553,967, June 30, 2009.

Olson; M.; Di Grandi, M. “Preparation Of Triazole Derivatives For Treating HIV Infections.” 2009, US Patent 7,563,905, July 21, 2009.

Levin, J. I.; Hopper, D. W.; Torres, N.; Dutia, M. D.; Berger, D. M.; Wang, X.; Di Grandi, M. J.; Zhang, C.; Dunnick,A.L. “Preparation Of Bridged, Bicyclic Heterocyclic Or Spiro Bicyclic Heterocyclic Derivatives Of Pyrazolo[1,5-A]Pyrimidines as RAF Kinase Inhibitors”, Pct Int. Appl., 2009, 159 PP; WO 2009108838 A1.